Roles of Th_1/Th_2 type cytokines in experimental autoimmune neuritis
- VernacularTitle:Th_1/Th_2型细胞因子在实验性自身免疫性神经炎发病机制中的作用
- Author:
Yun WU
;
Hua-Bing WANG
;
Wei-Zhi WANG
;
- Publication Type:Journal Article
- Keywords:
Neuritis,experimental allergic;
Cytokines;
Sciatic nerve
- From:
Chinese Journal of Neurology
2005;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the model of P2 peptide-induced experimental autoimmune neuritis(EAN)in rats and explore the roles of Th_1/Th_2 type eytokines in EAN.Methods Lewis rats were grouped into EAN rats and control rats.The EAN rats were immunized by injection into both hind footpads of inoculums containing 100 ?g or 200 ?g of P2_(57-81)peptide and FCA while the control rats were immunized with FCA only.Clinical scores were compared at the maximum of disease.Supernatant productions of IFN- ?, IL-4 and IL-10 secreted by lymphocytes and obtained on day 14 after the immunization were examined. Histopathological assessment of sciatic nerves was made.Results Peak clinical scores of P2_(57-81)200 ?g (3.6?0.3)group were significantly higher than P2_(57-81)100 ?g group(2.2?0.6,P
