Expression of heparanase protein and its relationship with prognosis in transitional cell carcinoma of bladder
- VernacularTitle:乙酰肝素酶在膀胱移行细胞癌中的表达及其与预后的关系
- Author:
Guang-Wei ZHENG
;
Yi-Qi LUO
;
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Heparanase;
Prognosis;
Immunohistochemistry
- From:
Cancer Research and Clinic
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of heparanase in transitional cell carcinoma of bladder(TCCB) and its correlation with prognosis in bladder cancer.Methods The expression of heparanase protein and microvessel formation was assessed by immunohistochemical staining in 80 bladder cancer speci- mens resected at various stages of disease and 20 non-tumor bladder tissues (controls).Results The overall positive rate of heparanase in 80 cases of bladder carcinoma was57.5% (n=46),it was significantly higher than in non-tumor bladder tissues (P
