Expression of uPA protein in epithelial ovarian cancer and its relationship with the expression of uPAR and the clinic prognosis
- VernacularTitle:尿激酶型纤溶酶原激活物在卵巢上皮性癌组织中的表达与受体及临床预后的关系
- Author:
Yu-Yang ZHANG
;
Ci-Xia SHUAI
;
Fei-Yun ZHENG
;
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
Urinary plasminogen activator;
Prognosis
- From:
Cancer Research and Clinic
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of urokinase-type plasminogen activator (uPA) and its relation with expression of receptor (urokinase-type plasminogen activator receptor uPAR) in epithelial ovari- an cancer (OEC) and with the clinic prognosis.Methods Expression of uPA and uPAR protein was detected by Streptavidin-biotin-HRP in 68 cases of epithelial ovarian cancer and compared with that in 10 cases of borderline tumor,10 cases of benign tumor and 10 cases of normal tissue,and correlation between them was analyzed.The different expression groups of uPA was correlated with the prognosis of ovarian epithelial can- cer.The expression of uPA showed a correlation with short survival time (P
