Expression of high-risk HPV and p53,p21~(WAF1),MDM2 in cervical squamous cell carcinoma
- VernacularTitle:高危人乳头状瘤病毒和p53、p21~(WAF1)、MDM2在子宫颈鳞癌中的表达
- Author:
Su-Hong LI
;
Feng-Qing LIU
;
Quan-Hong WANG
;
Yue-Hua WANG
;
Fang-Chun GONG
;
Li-Wu XIE
;
- Publication Type:Journal Article
- Keywords:
Uterine neoplasms;
Papillomarirus,human;
Protein p53;
Proto-oncogene protein p21(ras)
- From:
Cancer Research and Clinic
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the expression of HPV16/18,31/33 DNA and p53,p21~(WAF1) and MDM2 proteins in invasive squamous cell carcinoma of cervix (ISCC)and to indicate the significance of them in the occurrence and development of ISCC.Methods Using tissue microarray,in situ hybridization (ISH) and immunohistochemical method,we detected the expression of HPV16/18,31/33 and investigate the expres- sion of p53,p21~(WAF1),MDM2 and proteins in ISCC,CIN and NCE.Results was analysed by SPSS vision 12.5. Results The positive expression rate of HPV16/18,p53,p21~(WAF1),MDM2 in ISCC was markedly higher than in CIN and NCE.We found the difference between HPV31/33 and lymph node transfer.Significant relation- ship was observed between p53 protein expression and histological grade and lymph node metastasis of the cancer.There was positive correlation between the expression of p21~(WAF1) protein and the depth of invasion(P
