Effects of rosiglitazone on myocardial ultrastructure and atrial natriuretic factor mRNA expression in streptozocin-induced diabetic rats
- VernacularTitle:罗格列酮对糖尿病大鼠心肌超微结构、心钠素mRNA表达的影响
- Author:
Ying-Li LU
;
Hui WU
;
Hui ZHU
;
Chao SHI
;
Lan ZHU
;
Yu-Ping PANG
;
Yu-Guo YANG
;
Wan-Ling WU
;
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,experimental;
Myocardium;
Microstructure;
Atrial natriuretic factor;
Rosiglitazone
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The uhrastructure and atrial natriuretic peptide(ANP)mRNA in myocardium of streptozotocin-induced diabetic rats were studied along with the effect of rosiglitazone.It was found that the myocardial ultrastructure was demaged in diabetic rats.Rosiglitazone may ameliorate the lesion in myocardium,and lower the ANP mRNA in diabetic rats(1.14?0.05 at 6 weeks and 1.12?0.09 at 10 weeks vs 0.97?0.14,both P
