Understanding of obesity pathogenesis from human energy metabolism evolution perspective
- VernacularTitle:从人类能量代谢进化视角理解肥胖发生机制
- Author:
Jing WU
;
Hong-Wei WANG
;
Yu WEN
;
- Publication Type:Journal Article
- Keywords:
Obesity;
Evolution;
Polymorphism,genetic;
Peroxisome proliferator-activated receptors;
PPAR?coactivator-1
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
This article elucidates the relationship between the human susceptibility to obesity and gene polymorphisms such as peroxisome proliferators-activated receptors(PPARs)and PPAR?coactivator-1,along with milestones in the formation and development of capacity for fat deposition during evolutionary history of human.An biological evolutionary analysis,identifying factors favoring the energy stores,may be helpful to the development of preventive public health strategies.
