Insulin receptor substrate expression and insulin resistance in intrauterine growth retarded rats
- VernacularTitle:宫内发育迟缓幼鼠胰岛素受体底物表达与胰岛素抵抗
- Author:
Qian WANG
;
Yan-Qin YING
;
Qin NING
;
Xiao-Ping LUO
;
- Publication Type:Journal Article
- Keywords:
Fetal growth retardation;
Rat,Sprague-Dawley;
Insulin resistance;
Insulin receptor substrates;
Metabolic syndrome
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Insulin receptor substrate(IRS)-1 and IRS-2 expression levels of liver tissues and skeletal muscle in intrauterine growth retarded(IUGR)rats were investigated by RT-PCR and immunohistochemistry.An IUGR animal model was established by maternal nutrition restriction during pregnancy.IRS-2 expression level of liver tissue and IRS-1 expression level of skeletal muscle in IUGR rats at 0 and 3 weeks old were significantly lower than those in normal rats at the same age respectively,and insulin resistance was induced in IUGR,and these findings might be the molecular mechanisms susceptible to metabolic syndrome in IUGR rats.
