Expressions and significance of human telomerase reverse transcriptase mRNA and protein in pheochromocytoma
- VernacularTitle:人类端粒酶逆转录酶mRNA和蛋白在嗜铬细胞瘤中的表达及其意义
- Author:
Zuo-Jie LUO
;
Jian-Ling LI
;
Yin-Fen QIN
;
Min-Yi WEI
;
Xing-Huan LIANG
;
Jing XIAN
;
De-Cheng LU
;
Yu SHEN
;
Hua-Sheng LIANG
;
- Publication Type:Journal Article
- Keywords:
Phaeochromocytoma;
Paraganglioma;
Human telomerase reverse transcriptase
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of human telomerase reverse transcriptase(hTERT) mRNA and protein in pheochromocytoma and paraganglioma and their significance as diagnostic markers in predicting the biological behaviour of these tumours.Methods Expression of hTERT mRNA was determined by in situ hybridization in 45 pheochromocytomas/paragangliomas(31 benign,7 suspected malignant and 7 malignant) and 9 normal adrenal medulla samples,hTERT protein was determined by immunohistoebemistry.Results hTERT mRNA was expressed in 5/7 malignant turnouts and 5/7 suspected malignant tumours as compared with 3/31 benign tumours(P
