Effect of prostaglandin E_1 on renal blood flow and serum endothelin in early stage after liver transplantation
- VernacularTitle:肝移植术后应用前列地尔对血清内皮素和肾脏血流的影响
- Author:
Xiao-Sheng QI
;
Zhi-Hai PENG
;
Guo-Qiang QIU
;
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Prostaglandin E_1;
Renal function
- From:
Chinese Journal of Organ Transplantation
2005;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
To assess the effect of prostaglandin E_1(PGE_1)on renal blood flow and serum endothelin of liver recipients.Methods PGE_1 was administered in 38 liver recipients at the dose of 0.6?g?kg~(-1)?h~(-1)during liver transplantation and every day after operation.The effects of PGE_1 on serum endothelin concentration and creatinine(Cr)were observed and these indexes were compared with those in the control group(n=18).The renal blood flow resistance indexes(RI)were measured by Doppler ultrasound.Results Cr and RI were significantly lower in PGE1=treated group than those in the control group.PGE_1-treated group also showed a significantly lower serum endothelin concen- tration.Conclusion Administration of PGE_1 in liver recipients can significantly improve the early re- nal function by reducing serum endothelin concentration and dilating renal blood vessels.
