Association study between COL3A1 gene polymorphisms and ischemic stroke
- VernacularTitle:Ⅲ型胶原基因COL3 A1多态性与脑梗死的相关性
- Author:
Hai-Xia ZHU
;
Zhao-Jun ZENG
;
Xiao-Hong ZI
;
Kun-Lu WU
;
Zhi SONG
;
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Collagen type Ⅲ;
Polymorphism(genetics);
Polymerase chain reaction
- From:
Chinese Journal of Neurology
2005;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characters of the COL3A1 gene polymorphisms in Chinese population of Hunan region and the relationship between the COL3A1 gene polymorphisms and ischemie stroke.Methods Objects examined were composed of 70 healthy controls,110 patients with acute cerebral infarction.The frequencies of the genotypes were detected by using PCR-SSLP techniques and correlated PCR segements were analyzed by directly sequence to detect the COL3A1 gene polymorphisms.Result There were significant differences in the distribution of VNTR with COL3A1 genotype polymorphism between the patients of acute cerebral infarction and healthy controls,the former being 0.93,the latter 0.43,with a significant difference(P
