The clinical observation of oxaliplatin combined with capecitabin for patients with advanced colorectal cancer
- VernacularTitle:草酸铂联合卡培他滨治疗晚期大肠癌临床观察
- Author:
Xin-Jian RUAN
;
Jian-Fei WANG
;
Zhi GUO
;
Zhao-Liang CHEN
;
Xia ZHANG
;
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Oxaliplatin;
Capecitabine;
Drug therapy,combination
- From:
Cancer Research and Clinic
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effect and toxicity reaction of Oxaliplatin com- bined with XeLoda in the treatment of 42 patients with advanced colorectal cancer.Methods All the pa- tients were treated with Oxaliplatin(130 mg/m~2,ivgtt for 2 h,d1)combined with XeLoda(2000 mg?m~(-2)?d~(-1), po,bid,d1 to d14).The regime was repeated every 21 days for at least 3 consecutive cycles.Results The to- tal response rate was 40.5%(17/42)in which 2 got CR and 15 PR.24 patients got Kamofsky score increased. The major toxic effects were alopecia,peripheral neuritis,gastrointestinal tract reactions and myelosuppression. Conclusion Oxaliplatin combined with XeLoda regimen is effective in the treatment of advanced colorectal cancer,and its toxicity is tolerable.It is worth studying in the future.
