Distribution of calcium-sensing receptor gene polymorphism and its association with serum calcium level in patients with primary hyperparathyroidism
- VernacularTitle:原发性甲状旁腺功能亢进症患者钙敏感受体基因多态性的分布及其与血钙水平的相关性
- Author:
Ou WANG
;
Xun-Wu MENG
;
Xiao-Ping XING
;
Wei-Bo XIA
;
Mei LI
;
Ling XU
;
Xue-Ying ZHOU
;
Jie JIAO
;
Ying-ying HU
;
Huai-cheng LIU
;
- Publication Type:Journal Article
- Keywords:
Hyperparathyroidism;
Receptors;
calcium-sensing;
Polymorphism;
genetic;
Calcium;
Parathyroid hormone
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).Conclusion The distribution of G990R CASR genotype in PHPT patients is different from healthy women,and R allele is higher in PHPT group.Among PHPT patients,A986S and G990R polymorphisms are associated with serum calcium and ICa levels.Patients with S or G allele have lower levels of serum calcium and ICa.A986S genotype is also associated with serum PTH level and patients with S allele have relatively lower level of PTH.
