Effects of genistein and 17?-estradiol on microstructure of cancellous bone in ovariectomized rats
- VernacularTitle:染料木素和17?-雌二醇对去卵巢大鼠松质骨微结构的作用
- Author:
Ru-Chun DAI
;
Ling-Na FANG
;
Zhi-Feng SHENG
;
Hui-Jie FAN
;
Jian-Ping HAO
;
Kang XU
;
Xian-Ping WU
;
Er-yuan LIAO
;
- Publication Type:Journal Article
- Keywords:
Genistein;
Estradiol;
Ovariectomy;
Bone and bones;
MicroCT
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of genistein and 17?-estradiol on microstructure of cancellous bone in ovariectomized (OVX) rats.Methods Ninty 7-month-old SD rats were randomly divided into baseline group,ovariectomized (OVX),sham-operated (SHAM),17?-estradiol treated (10?g?kg~(-1).day~(-1),EST) and genistein treated (5 mg?kg~(-1)?day~(-1),GEN) groups,and were killed at the beginning of the experiment,the 3rd and 15th week after operation.MicroCT scanning was performed on the left tibia in vitro.The regions involving 0.5 mm slice thickness and 1.6 mm distal to the tibial growth plate were selected as the regions of interest.Results At the 3rd week after operation,the tissue bone mineral density (tBMD) and trabecular thickness (sTh.Th) in group GEN were significantly higher than those in OVX and EST groups (all P
