Regulating effect of 17?-estradiol on osteoprotegerin and osteoclast differentiation factor expressions in osteoblasts from newborn rats
- VernacularTitle:17?-雌二醇对新生大鼠成骨细胞护骨素和破骨细胞分化因子表达的调节
- Author:
Qian XIONG
;
Xiu-Zhen ZHANG
;
- Publication Type:Journal Article
- Keywords:
Estradiol;
Osteoblasts;
Osteoprotegerin;
Osteoclast differentiation factor
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Osteoblasts (OB) isolated from newborn SD rats were cultured in vitro.After treatment with different concentrations of 17?-estradiol (10~(-11)-10~(-6)mol/L),the mRNA expressions of osteoprotegerin (OPG) and osteoclast differentiation factor (ODF) in OB were measured by RT-PCR.17?-estradiol increased the expression of OPG in OB with the maximal effect at the concentration of 10~(-8) mol/L.No significant difference was observed in the expression of ODF in OB with different concentrations of 17?-estradiol.The therapeutic effect of estrogen on osteoporosis appears to be related to the enhanced OPG expression in OB at physiological concentration of estrogen.
