Relationship between plasma osteoprotegerin and endothelium-dependent arterial dilation in type 2 diabetic patients
- VernacularTitle:2型糖尿病患者护骨素与内皮依赖性血管舒张功能的关系
- Author:
Guang-Da XIANG
;
Hui-Ling SUN
;
Lin-Shuang ZHAO
;
Ling XU
;
- Publication Type:Journal Article
- Keywords:
Osteoprotegerin;
Vascular endothelial dysfunction;
Diabetes mellitus;
type 2
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the relationship between plasma osteoprotegerin (OPG) level and endothelium-dependent arterial dilation (EDAD) in type 2 diabetic patients.Methods The subjects included 40 newly diagnosed type 2 diabetic patients and 46 healthy subjects.Insulin therapy were then given to all diabetic patients for 6 months.Plasma OPG was measured by a sandwich ELISA method,and brachial artery diameter was determined by high resolution ultrasound at rest after reactive hyperemia and after sublingual glyceryl trinitrate (GTN).Results Plasma OPG level in diabetic patients before treatment was (3.44?0.52) ng/L,which was significantly higher than that in control (2.38?0.25 ) ng/L (P
