Chromosomal localization of primary gout susceptibility gene in a Chinese pedigree
- VernacularTitle:一个原发性痛风家系致病易感基因染色体定位
- Author:
Chang-Gui LI
;
Ying CHEN
;
Chao XU
;
Zhi-Min MIAO
;
Sheng-Li YAN
;
Huai-Dong SONG
- Publication Type:Journal Article
- Keywords:
Gout;
Pedigree;
Chromosome mapping
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine chromosomal localization of the primary gout susceptibility gene in a pedigree.Methods The clinical data and the peripheral blood samples were collected in the pedigree members and the genomic DNA was extracted from peripheral blood.A genome-wide screening was performed using 400 micro-satellite DNA markers in this family,and linkage analysis was used to determine the chromosomal location of the primary gout susceptibility gene.Results Linkage analysis showed that the maximum LOD score reached 1.50 at marker D4S1572 (at recombination fraction?=0.00).Conclusion Since D4S1572 is localized at 4q25,the primary gout susceptibility gene of this pedigree is localized at 4q25.
