Association between Graves'disease and polymorphism of CTLA-4 gene in patients of the Han nationality in Tianjin area
- VernacularTitle:天津地区汉族人Graves病与CTLA-4基因多态性的关联
- Author:
Peng ZHANG
;
Mei LI
;
Yong ZHAO
;
Meng-Hua YUAN
;
Ming-Cai QIU
;
- Publication Type:Journal Article
- Keywords:
CTLA-4 gene;
Graves' disease;
Graves' ophthalmopathy;
Polymorphism;
genetic
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The polymorphism of (AT) repeat within the 3' untranslated region in exon 3 of CTLA-4 gene was evaluated by PCR-SSCP in 139 patients with Graves' disease (GD) and 110 normal subjects in Tianjin. The gene frequency of 106 bp in patients with GD was significantly increased than that in the control group (RR =1.992,P
