Application of salivary cortisol test for diagnosis of Cushing′s syndrome
- VernacularTitle:唾液皮质醇检测在皮质醇增多症诊断中的应用
- Author:
Wei-Wei ZHOU
;
Wei-Qing WANG
;
Guang NING
;
Ting-Wei SU
;
Lei JIANG
;
Na ZHU
;
Yu-Fang BI
- Publication Type:Journal Article
- Keywords:
Hydrocortisone;
Saliva;
Cushing syndrome;
Radioimmunoassay
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
A total of 121 subjects comprising 40 normal subjects,58 patients with overweight or obesity and 23 patients with Cushing's syndrome were recruited in the study.The modified radioimmunoassay (RIA) for salivary cortisol test was established'and its normal range was determined.Then the diagnostic value of the salivary cortisol for the initial diagnosis of Cushing's syndrome was evaluated and single midnight salivary cortisol test demonstrated a sensitivity of 100.0% and specificity of 91.4 %.Salivary cortisol test can be recommended as a first-line diagnostic parameter for Cushing's syndrome.
