Expression of matrix metalloproteinase-9 and intercellular adhesion molecule-1 in the perihematomal tissues in human hypertensive intracerebral hemorrhage and its significance
- VernacularTitle:高血压性脑出血患者血肿周围组织基质金属蛋白酶-9和细胞间黏附分子-1的表达及意义
- Author:
Shu-Rong DUAN
;
Song-Bin FU
;
Chun-Yan WANG
;
Xiao-Ran WANG
;
De-Sheng WANG
;
Ji-Ping QI
;
Hai-Tao WANG
- Publication Type:Journal Article
- Keywords:
Intracerebral hemorrhage,hypertensive;
Brain edema;
Gelatinase B;
Intercellular adhesion molecule-1
- From:
Chinese Journal of Neurology
1999;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the expression of matrix metalloproteinase-9 (MMP-9) and intercellular adhesion molecule-1 (ICAM-1) in the perihematomal tissues in human hypertensive,intracerebral hemorrhage (ICH) and brain edema formation following ICH.Methods Paraffin-embedded brain tissues of 39 human fatal cases of ICH from the perihematomal tissues,1—3 cm away from the margin of the hemorrhagic lesion,as well as tissues from the corresponding area at the opposite side as controls,were stained with HE and immunohistochemistry staining.The expressions of MMP-9 and ICAM-1 in the pefihematomal tissues were analyzed with the SPSS 11.5 system.Results ①With MMP-9 immunohistochemical staining positive capillaries in the perihematomal tissues were identified at 2 h ((1.2? 0.8)/HP).The number of MMP-9 positive capillaries began to rise at 5—10 h ((4.1?0.8)/HP) reaching the peak at 45—48 h ((10.6?1.4)/HP,P
