Polymorphism of ATP-binding cassette transporter A1 gene in sporadic Alzheimer's disease
- VernacularTitle:三磷酸腺苷结合盒转运子A1基因多态性与散发性阿尔茨海默病的关系
- Author:
Fen WANG
;
Jian-Ping JIA
;
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
ATP-binding cassette transporter;
Polymorphism(genetics)
- From:
Chinese Journal of Neurology
1999;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of the single nucleotide polymorphisms (SNPs)G→A (R219K) in the exon 6 of ATP-binding cassette transporter A1 (ABCA1) gene with sporadic Alzheimer's disease (SAD) in the Han Chinese population.Methods Genotypes were determined by PCR-restriction fragment length polymorphism (PCR-RFLP) in 168 SAD patients and 215 healthy controls. The association between the polymorphism and AD was estimated with the odds ratios (OR).Results The frequency of A allele in SAD cases was significantly lower than in controls (37.8 % vs 48.1%,x~2=8.204, P=0.004),and the frequency of AA genotype in SAD cases was also significantly lower than in control (14.3% vs 22.8%,x~2=8.230,P=0.016).Logistic regression analyses adjusted for age,gender and ApoEe4 status showed that the risk for AD was decreased in A allele (G/A+A/A genotypes,OR 0.57, 95% CI 0.36—0.91,P=0.019) or AA homozygote carriers (OR 0.40,95% CI 0.21—0.77,P= 0.006) compared with GG genotypes carriers.Conclusion Our data indicate a genetic association between polymorphism in exon 6 of ABCA1 gene and the risk of AD and reveal that AA genotype or A allele of ABCAI gene may have a protective effect on AD in the Han Chinese.
