Change of ?-amyloid precursor protein processing in platelet of Alzheimer's disease patients
- VernacularTitle:阿尔茨海默病患者血小板淀粉样前体蛋白代谢的改变
- Author:
Xiao-Qin HUANG
;
Jian-Ping JIA
;
Chun-Qiu FAN
;
Xiu-Min DONG
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Blood platelets;
Amyloid beta-protein precursor
- From:
Chinese Journal of Neurology
1999;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristic of ?-amyloid precursor protein (A?) processing in activated platelet in AD.Methods Thirty-six sporadic AD patients and 30 control subjects were included in this study.Blood was collected from the subjects to separate platelets.After treated by thrombin,the soluble amyloid precursor protein (APP) level in the snpernatants of platelets from 36 were analyzed by means of western blot with a specific antibody recognizing soluble APP.Meanwhile A? level was measured by radioimmunoassay.Results After treated with thrombin,the level of soluble APP in the supernatants of platelets in patients with AD decreased by 31.0% (P
