Mapping and analysis of HPV16 integration sites in a cervical cancer cell line
- VernacularTitle:利用FISH分析HPV16在Hela细胞中的整合位点
- Author:
Li-Ping LI
;
Man-Li SUN
;
Guo-Can LING
;
- Publication Type:Journal Article
- Keywords:
Cervix neoplasms;
HPV16;
DNA probes,HPV;
In situ hybridization,fluorescence;
Hela cell line
- From:
Cancer Research and Clinic
1999;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the chromosome aberration of cervical cancers induced by human papillomavirus(HPV16)virus.Methods The change of change of chromosomes of Hela cells induced by HPV-16 infection HPV-16 in fection was detected by FISH.Results The integration sites of HPV-16 were not observed in Hela cells.But HPV16 virus was integrated on chromosomes 3.Conclusion HPV16 could cause chromosome 3 aberration in Hela cells and result in the occurance of cervical cancers.
