Significance of the expression of cyclooxygenase-2 in breast cancers
- VernacularTitle:环氧化酶-2在乳腺癌组织中的表达及其临床意义
- Author:
Miao XU
;
Yang WANG
;
Xiu-Xin YAN
;
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Epoxy compounds;
Immunohistochernistry
- From:
Cancer Research and Clinic
1999;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of cyclooxygenase-2(COX-2)in breast cancers, and understand its clinical significance.Methods The immunohistochemistry was used to determine the ex- pression of COX-2 in the 40 tissues of breast cancer and 18 adjacent noncancerous mammary tissues.Results The positive expression of COX-2 was detected in 52.5% of breast cancer tissues and in 11.1% of adjacent noncancerous mammary tissues.There was a significant difference in the expression of COX-2 between breast cancer tissues and adjacent noncancerous mammary tissues(P0.05).Conclusion COX-2 was over expressed in breast cancer and correlated with metastatic lymph nodes and HER-2/neu.The expression of COX-2 may play an important role in carcinogen- esis,progression and prognosis of breast cancer.
