The expression of VEGF,COX2 and mPGES mRNA in colon cancer
- VernacularTitle:VEGF、COX-2、mPGES mRNA在结肠癌中的表达及其意义
- Author:
Bo JIANG
;
Dong-Bo LIU
;
Wen-Yuan WANG
;
Wei-Lan LIU
;
Su-Tang GUO
;
- Publication Type:Journal Article
- Keywords:
Colonic neoplasms;
VEGF;
Prostaglandins E
- From:
Cancer Research and Clinic
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of VEGF,Cox2 and mPGES in colon cancer.Methods VEGF,Cox2 and mPGES mRNA expression in 32 paired samples(tumor and adjacent normal tissue)were de- termined by using real time RT-PCR.Results VEGF was overexpressed in 19 of 32(59.3 %)tumor tissues compared with that in 6 of 32(18.7 %)adjacent normal tissue;COX2 was overexpressed in 20 of 32(62.5 %) tumor tissues compared with that in 5 of 32(15.6 %)adjacent normal tissue;mPGES was overexpressed in 24 of 32(75 %)tumor tissues compared with that in 9 of 32(28.12 %)adjacent normal tissue.Conclusion Our result suggested that VEGF165,mPGES and COX2 overexpressed in colon cancer.
