Clinical study on taxol plus 5-fluorouracil/leucovorin combination chemotherapy for patients with advanced gastric cancer
- VernacularTitle:紫杉醇联合5-氟尿嘧啶、亚叶酸钙方案治疗晚期胃癌近期疗效评价
- Author:
Lu WEN
;
Yu-Sheng WANG
;
- Publication Type:Journal Article
- Keywords:
Gastric neoplasms;
Antineoplastic combined chemotherapy protocdls;
Fluorouracil;
Taxol
- From:
Cancer Research and Clinic
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The current study was designed to evaluate the efficacy and toxicity of taxol plus fluorouracil(TF)chemotherapy in patients with advanced gastric cancer.Methods 55 patients with ad- vanced gastric cancer were treated with TF schedule.A treatment cycle lasted 21 days.The efficacy was eval- uated after 2～3 cycles of the chemotherapy.Results These 55 patients were evaluated the efficacy and the toxicity.The total efficiency rate of TF schedule was 45.45 %.Clinical Benefit Response(CBR)were evaluated in 35 patients.Ache remission rate was 86.6 %.The main side effect of toxicity was neutropenia.The total re- sponse neutropenia is 56.4 %.The aboveⅢstage was 10.9 %.The rate of nausea and vomiting was 43.6 %. Conclusion The combination of taxol and fluorouracil is a high response protocol with mild toxicity.TF schedule has high efficiency for advanced gastric cancer,especially for the patients who had had chemothera- py with fluorouracil.
