The study on induced expression of heat-shock protein(HSP)70s in lung carcinoma patients
- VernacularTitle:肺癌患者热应激蛋白70诱导表达能力的研究
- Author:
Feng LIANG
;
Jin-Ping ZHENG
;
Wen-Liang MA
;
Feng WANG
;
Tang-Chun WU
;
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Heat-shock proteins;
Disease susceptibility
- From:
Cancer Research and Clinic
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression level of HSP72 and HSP73,the subtypes of HSP70, in peripheral blood lymphocytes from lung carcinoma patients on both basic and heat injury conditions,and to explore the significance of HSP70 in the development of lung cancer.Methods Lung cancer patients were selected'as experimental group,and the health people with similar age,gender,vocational history and inhabi- tation to the experimental group were chosen as control group.The blood lymphocytes from both groups were isolated,cultured and treated with heat injury at either 37℃or 42℃.The expressions of HSP72 and HSP73 in the isolated lymphocytes were determined by Flow Cytometry.Results There were much higher expressions of HSP72 and HSP73 in control group(21.97?2.40 vs 12.77?0.66)than which in experimental group(HSP72 19.0?2.12 vs HSP73 11.74?0.68,P
