Effect of Tripterygium wilfordii polyglycosidium on caspase expression of islet?-cell in NOD mice
- VernacularTitle:雷公藤多甙对NOD小鼠胰岛?细胞半胱天冬蛋白酶表达的影响
- Author:
Li-Ping GU
;
Yi-Jie WU
;
Yu-Fei WANG
;
Nian-Wei SHI
;
Wei-Ping DONG
;
Jian LIN
- Publication Type:Journal Article
- Keywords:
Tripterygium wilfordii ployglycosidium;
Diabetes mellitus,type 1;
Mice,inbred NOD;
Apoptosis;
Caspase
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
NOD mice were treated intraperitoneally with tripterygium wilfordii ployglycosidium (TWP) for 4 weeks to observe the incidence of cyclophosphamide accelerated diabetes.The apoptosis of?-cells was detected by TUNEL,the expression of caspase-3 in islets of the NOD mice was detected by immunohistochemistry and the expression of caspase-8 mRNA in pancreas by RT-PCR.The results revealed that the incidence of diabetes in TWP group was lower than that in control group.The apoptosis index of?-cells was decreased in TWP group. The expression of caspase-3 in islets and the expression of caspase-8 mRNA in pancreas in TWP group were lower than those in control group.
