Evaluation of insulin secretion and insulin sensitivity in the selection of hypoglycemic drugs——a mulficentre clinical study
- VernacularTitle:评估胰岛素分泌及胰岛素敏感性选择降糖药物的临床多中心研究
- Author:
Yu-Qian BAO
;
Wei-Ping JIA
;
Xin GAO
;
Wei LIU
;
Hui-Li XING
;
Zhi-Min LIU
;
Zheng-Yan SHENG
;
Ren-ming HU
;
Guang NING
;
Da-jing ZOU
;
Bo FENG
;
Jun-xi LU
;
Jian ZHOU
;
Kun-san XIANG
;
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Arginine stimulation test;
First-phase insulin secretion;
Insulin resistance
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the pathophysiological change of diabetes and its significance in the treatment of newly-diagnosed type 2 diabetic patients.Methods A total of 322 newly-diagnosed type 2 diabetic patients were included in this study and were divided into 2 groups with normal or impaired islet first-phase insulin secretion according to arginine stimulation test.The former group was assigned to repaglinide (Novo Norm), rosiglitazone (Avandia) and mefformin subgroups and the latter one to repaglinide,rosiglitazone and glipizide subgroups randomly.Results (1)Compared with baseline,fasting plasma glucose,2 h postprandial plasma glucose and HbA_(1C) were significantly decreased in all subgroups after 3 and 6 months of treatment (all P
