Effects of losartan and amlodipine on plasma leptin and adiponectin levels and insulin sensitivity in obese hypertensive patients
- VernacularTitle:氯沙坦和氨氯地平对肥胖高血压患者瘦素、脂联素及胰岛素敏感性的影响
- Author:
Chang-Mei LIU
;
Hui-Pu XU
;
Hui-Ying XU
;
Chang-Shan LIU
;
- Publication Type:Journal Article
- Keywords:
Hypertension;
Obesity;
Leptin;
Adiponeetin;
Losartan;
Amlodipine
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of losartan and amlodipine on blood pressure,plasma levels of leptin,adiponectin and norepinephrine (NE) and insulin sensitivity in obese hypertensive patients.Methods The levels of plasma leptin and adiponectin were determined by RIA and the plasma NE level was assayed by high- performance liquid chromatography.Insulin resistance index (HOMA-IR) was evaluated using the homeostasis model.Results Compared with basal levels,after 16-weeks' therapy,plasma leptin,HOMA-IR and body mass index were significantly decreased in losartan group [(35.6?18.5 vs 32.0?17.1)?g/L,P
