Expression of human rearranged immunoglobulin?light chain 022 in omental adipose tissues of type 2 diabetic patients
- VernacularTitle:人类重组免疫球蛋白?轻链022在2型糖尿病患者网膜脂肪组织的表达
- Author:
Wei-Min ZHAO
;
Jun-Jie ZOU
;
Yong-Quan SHI
;
Xiu-Lan ZOU
;
Jiao-Yang ZHENG
;
Zhi-Min LIU
- Publication Type:Journal Article
- Keywords:
Insulin resistance;
Adipose tissue;
Immunoglobulins,?-chain
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
In adipose tissues from sreater omentum of patients with type 2 diabetes,the mRNA and protein expressions of human rearranged immunoglobulin?light chain (HSIGVL) 022 were measured by the fluorescent quantitative RT-PCR and immunohistochemistry respectively.The results showed that mRNA and protein levels of HSIGVL022 were up-regulated in patients with type 2 diabetes.The mRNA level of HSIGVL022 was linearly correlated with insulin resistance index,suggesting that this gene may play a role in the pathogenesis of insulin resistance and type 2 diabetes.
