Urinary protein profile of type 2 diabetic nephropathy and diagnostic decision tree
- VernacularTitle:2型糖尿病肾病尿液蛋白质谱及诊断决策树模型的建立
- Author:
Ye-Hong YANG
;
Shuo ZHANG
;
Bin LU
;
Wei-Wei LIU
;
Xiao-Yan SONG
;
Xue-Hong DONG
;
Xi-Xing ZHU
;
Ren-ming HU
;
- Publication Type:Journal Article
- Keywords:
Surface enhanced laser desorption/ionization time-of-flight mass spectrometry;
Diabetic nephropathies;
Decision tree
- From:Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Urine samples from 72 patients with diabetic nephropathy (DN) were analyzed and compared to those from 33 diabetic patients without albuminuria and 29 normal controls,using SELDI-TOF-MS (surface enhanced laser desorptiort/ionization time-of-flight mass spectrometry) and Biomarker Patterns Software,to identify differences in protein profile,generate a tree analysis pattern and evaluate the validity of the decision tree.The intensities of 6 peaks detected appeared upregulated,while 11 peaks downregulated,in DN group as compared to nonDN groups more than 2 folds (P
