Association of E23K polymorphism of inwardly rectifying K~+channel 6.2 gene with the phenotype of type 2 diabetes and glucose-lowering effect of gliclazide
- VernacularTitle:内向整流钾通道6．2基因E23K多态性与2型糖尿病表型及格列齐特降糖疗效的关系
- Author:
Li-Li CHEN
;
Qiang LI
;
Hou-Xun XING
;
Xiao-Wei REN
;
Yu-Qian SUN
;
Feng-Chen LIU
;
Mei-Hua LIANG
;
Zhong ZHANG
;
Jin-chao ZHANG
;
- Publication Type:Journal Article
- Keywords:
Potassium channel,inwardly rectifying;
Polymorphism,single nucleotide;
Diabetes mellitus,type 2;
Gliclazide
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The influences of E23K polymorphism of inwardly rectifying K~+channel 6.2 (Kir6.2) gene on the clinical phenotype of type 2 diabetes and glucose-lowering effect of gliclazide were investigated.The result showed that E23K polymorphism did not influence glucose-lowering effect of gliclazide,but serum creatinine level of patients with K/K genotype was higher than those of E/E and E/K genotypes (P
