Islet-like cells in bone marrow of streptozotocin-induced diabetic rats
- VernacularTitle:链脲佐菌素所致糖尿病大鼠骨髓中存在胰岛样细胞
- Author:
Xiao-Hong WU
;
Jian ZHU
;
Jing-Jing JIANG
;
Cui-Ping LIU
;
Xiao-Dong MAO
;
Kuan-Feng XU
;
Yu XU
;
Chao LIU
;
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Bone marrow cells;
Islet-like cells
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The present study demonstrated that bone marrow cells from diabetic rats were able to form cell clusters expressing insulin,C-peptide,glucagon,somatostatin and islet amyloid .polypeptide,and other genes associated with development and function of islets such as glucose transporter-2,glucokinase,glucagon-like peptide-1 receptor,PDX-1,Ngn3,NeuroDl,Pax-6 and NKX2.2 genes.These islet-like cells might be derived from adult stem cells in bone marrow.
