Role of angiotensinⅡin the changes of MMP-9 and TIMP-1 mRNA expressions in high glucose-induced mesangial cells of rat
- VernacularTitle:血管紧张素Ⅱ在高糖诱导大鼠系膜细胞MMP-9和TIMP-1 mRNA表达中的作用
- Author:
Hai-Yan LI
;
Ying GUO
;
He-Lin DING
;
Zu-Zhi FU
;
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinases;
Tissue inhibitors of matrix metalloproteinase;
High glucose;
AngiotensinⅡ;
Mesangial cells
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
High glucose stimulated angiotensinⅡ(ATⅡ) production in mesangial cells of rat.Both high glucose and ATⅡdecreased expressions of matrix metalloprotein-9 (MMP-9) mRNA and MMP-9/tissue inhibitor of metalloproteinase-1 (TIMP-1) mRNA ratio and increased TIMP-1 mRNA expression in mesangial cells of rat,which could be reversed by an ATⅡreceptor blocker,Saralasin.
