Insulin resistance of islet ?-cells
- VernacularTitle:胰岛?细胞的胰岛素抵抗
- Author:
Li-Juan ZHANG
;
Da-Jin ZOU
;
- Publication Type:Journal Article
- Keywords:
Islet?-cells;
Insulin resistance;
Obesity;
Diabetes mellitus,type 2
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
It has been proved recently that insulin signal transduction pathway and insulin resistance exist in islet?-cells.Defects in insulin signaling of the?-cells decrease glucose-stimulated first-phase insulin release, inhibit proliferation of?-cells and promote apoptosis of?-cells.Obesity accelerates the development of insulin resistance of?-cells,which may play a central role in the pathogenesis of type 2 diabetes mellitus.
