Effect of the intraperitoneal injection of ATP on denervated skeletal muscle atrophy and neurotrophic factor-3 in spinal cord motor neuron after brachial plexus injuries
- VernacularTitle:细胞外ATP对失神经骨骼肌和脊髓前角神经元NT-3的影响
- Author:
Wei-Hua HOU
;
Xiang-Dong YUN
;
Shuan-Ke WANG
;
- Publication Type:Journal Article
- Keywords:
Spinal cord motor neuron;
Brachial plexus;
Neurotrophicfactor-3 (NT-3);
Dener-vated skeletal muscle;
ATP
- From:
Chinese Journal of Microsurgery
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of ATP protection after brachial plexus injuries. Methods A total of 80 female Wistar rats,weighting 280～300 g,were randomly divided into ATP and con- trol groups.The right C_5～T_1 nerve roots were transected and then the intraperitoneal injection of 4m[ of ATP or normal saline was given immediately and once daily to the rats,respectively.The rats were sacrificed on postoperative days 14,28 and 42 respectively.The C_5-T_1 segments of the spinal cord were harvested.NT-3 activity was measured by enzymo-histochemistry method.Four weeks and 6 weeks postoperatively,ultrastruc- ture of the denervated skeletal muscles was observed.Results Compared to the control group,the expres- sions of NT-3 was increased in the treated groups with ATP injection (P
