The relationship between TGF-?signal transduction pathway and pathogenesis of gastric carcinoma
- VernacularTitle:转化生长因子?信号转导途径与胃癌发生发展的关系
- Author:
Jian-Hong GUO
;
Tao MA
;
Yun-Peng ZHANG
;
Wei-Qing DONG
;
Tao FENG
;
Ya-Tu GUO
;
Xing-Yu LIANG
;
Chao WANG
;
Wei-Shan QIN
;
Jian-Jin GUO
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Transforming gronth factor beta;
Immunohistochemistry
- From:
Cancer Research and Clinic
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between TGF-?signaling pathway and pathogenesis of gastric carcinoma.Methods The expression of TGF-?RⅠ,TGF-?RⅡand Smad4 protein was deter- mined by immunohistochemistry in normal gastric mucosa(26 cases),intestinal metaplasia(22 cases),dysplasia (20 cases)and gastric carcinoma(43 cases).Results The positive expression rate of TGF-?RⅠ,TGF-?RⅡand Smad4 decreased following the malignant degree in gastric tissues(P
