Relation between ABCA1 expression and carotid atherosclerotic plaques
- VernacularTitle:三磷酸腺苷结合盒运转体A1与颈动脉粥样硬化斑块的关系
- Author:
Heng-Fang LIU
;
Qi-Dong YANG
;
Wang MIAO
;
Shang-Shu QI
;
Hong-Lin DONG
;
Xi-Ming SONG
;
Geng-Shan HE
;
Fu-Quan ZHANG
;
- Publication Type:Journal Article
- Keywords:
Carotid artery disease;
ATP binding cassette transporters;
Receptors,restinoic acid
- From:
Chinese Journal of Neurology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of the expressions of ATP-binding cassette transporter A1(ABCA1)and the retinoid X receptor(RXR?in human carotid atherosclerotic plaques and to explore the possible mechanisms by which ABCA1 affects the formation of carotid atherosclerosis(CAS). Methods 24 carotid atherosclerotic plaque and 10 intestinal artery specimens were respectively collected to compared the expression levels of ABCA1 mRNA.RXR?mRNA and those protein,ABCA1 and RXR?gene expressions were determined by reverse transcriptase polymerase chain reaction(RT-PCR)in the specimens,meanwhile the presence of ABCAI and RXRcprotein was assessed by Western blot.Results ABCA1(0.79?0.04)and RXR?(0.73?0.04)gene expression were significantly elevated in carotid atherosclerotic plaques(P
