Effect of verapamil on electrobiological activity and seizure behavior in phenytoin-carbamazepine resistant rats
- VernacularTitle:维拉帕米对耐苯妥英钠和卡马西平癫癎模型大鼠电生理和行为的影响
- Author:
Ying-Hui CHEN
;
Yong-Bo ZHAO
;
Nai-Dong WANG
;
Ai-Mei MA
;
Deng-Jun GUO
;
Wen-Wen LIU
;
- Publication Type:Journal Article
- Keywords:
Epilepsy;
P-glycoprotein;
Verapamil;
Anticonvulsonts
- From:
Chinese Journal of Neurology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To invesgate the effect of P-glycoprotein(PGP)inhibitor,verapamil,on electrobiological activity and seizure behavior in phenytoin-carbamazepine(PHT-CBZ)resistant rats.Methods The model of medically intractable epilepsy was established by kindling of amygdale. Verapamil was applied to PHT-CBZ resistant rats,followed by the observation on after discharge threshold (ADT),after discharge duration(ADD)and seizure activity.Results Compared with the control group, the ADT was higher in PHT-CBZ resistant rats peritoneally injected with verapamil((238.0?32.2)?A vs (177.0?23.3)?A,P
