Clinical research on the therapeutic effects and safety of amitrine bismesylate in patients with mild vascular dementia
- VernacularTitle:阿米三嗪-萝巴新治疗轻度血管性痴呆的疗效和安全性
- Author:
Jian-Ping JIA
;
Xin WANG
;
Sen-Yang LANG
;
Zhong-Xin ZHAO
;
Xiao-Ping PAN
;
Li-Juan WANG
;
- Publication Type:Journal Article
- Keywords:
Dementia,vascular;
Amitrine;
Quality of life
- From:
Chinese Journal of Neurology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic effects and safety of amitrine bismesylate in patients with mild vascular dementia.Methods An open multicenter self-controlled trial was carried out with 128 mild vascular dementia patients clinically diagnosed.Patients were treated with amitrine bismesylate in a dose of 2 tablets per day for 12 weeks.The neuro-psychologieal scale of MMSE,ADAS-cog,CDR, ADL were used to evaluate patients′cognitive condition before therapy and 6,12 weeks after treatment.The adverse effects,such as nausea and vertigo and so on,were monitored at the same time to evaluate the safety of this drug.Results After 3 months of treatment,the MMSE score(16.98 before therapy and 17.97 after treatment,P
