Mechanisms of the subthalamic nuclei high frequency stimulation in Parkinson' s disease
- VernacularTitle:丘脑底核高频电刺激治疗帕金森病的机制
- Author:
Yong-Bo ZHAO
;
Qiao-Shu WANG
;
Bo-Min SUN
;
Xiao-Ping WANG
;
- Publication Type:Journal Article
- Keywords:
Parkinson' s disease;
Electric stimulation therapy;
Tyrosine 3-monooxygendse;
Subthalamic nucleus
- From:
Chinese Journal of Neurology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the effects of the subthalamic nuclei(STN)high frequency stimulation(HFS)on striatal and nigral dopaminergic metabolism in rats.Methods The effects of subthalamie nuclei high frequency stimulation(STN-HFS)on striatal dopaminergie metabolism was investigated in free moving rats.Reverse transcriptase polymerase chain reaction(RT-PCR)and Western blot of striatal and nigral tyrosine hydroxyiase(TH)were performed.Results Our data suggest that STN- HFS elevated TH protein(0.99?0.14 vs 0.33?0.08,P
