Investigation on neurofilament in immune-mediated spinal cord motor neuron injury
- VernacularTitle:免疫介导的脊髓前角运动神经元损伤过程中神经丝异常的观察
- Author:
Ya-Ling LIU
;
Yan-Su GUO
;
Lei XU
;
Shu-Yu WU
;
Dong-Xia WU
;
Ai-Bing REN
;
Hui-Yong HUO
;
Chun-yan LI
- Publication Type:Journal Article
- Keywords:
Amyotrophic lateral sclerosis;
Disease models,autoimmune,nervous system;
Motor neurons;
Neurofbrils
- From:
Chinese Journal of Neurology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between immune and pathogenesis of amyotrophic lateral sclerosis (ALS) in the investigation of neurofilaments phosphorylation and ultrastructure features in spinal cord ventral horn motor neuron injury mediated by immune.Methods Using transmission electron microscope,we studied the uhrastructure features of abnormal accumulations of neurofilaments (NF) in motoneuron of the spinal cord ventral horn,and immunohistochemically investigated neurofilaments phosphorylation.Results Electron microscope found that there was abnormal accumulation of interwoven NFs in motor neuronal perikarya and proximal axons.Immunohistochemical study revealed that the SMI-32 immunoreactive positive neurons (12.00?1.05),compared with control (18.00?1.83),were reduced (P
