Cognitive impairment in epileptic patients: neuropsychological and diffusion-tensor imaging study
- VernacularTitle:癫癎患者磁共振弥散张量成像及其与智能损害的关系
- Author:
Xiang-Qing WANG
;
Sen-Yang LANG
;
Hong LU
;
Lin MA
;
Yan-Ling MAO
;
Fei YANG
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Cognition disorders;
Diffusion magnetic resonance imaging
- From:
Chinese Journal of Neurology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the pathologic changes in the brain areas corresponding to specific cognitive function and underlying mechanism of cognitive impairment in patients with epilepsy by DTI study.Methods Forty-four Patients and 20 control subjects received the test of Wechsler Adult Intelligence Scale and the Diffusion-Tensor Imaging examination.Mean diffusivity (MD) and fractional anisotropy (FA) in the normal appearing white matter of interested area were measured.T test was employed to compare the MD and FA between patients and healthy controls,patients with normal and impaired FIQ respectively.The relationships between FIQ and DTI value were analyzed by Bivariate correlations.Results VIQ (100.52?17.63),PIQ (95.10?16.72) and FIQ (98.19?17.76) of the patients with epilepsy were significantly lower than those of health controls (VIQ,PIQ and FIQ were 109.77?13.54,108.11? 12.17 and 109.81?10.57,respectively).Significant reduction of FA in both side of posterior limb of internal capsule (P
