Study of the therapeutic effects of free radical scavenger edaravone on cerebral hemorrhage in rats
- VernacularTitle:自由基清除剂依达拉奉对大鼠脑出血的治疗作用
- Author:
Ling-Lin DONG
;
Fu-Qiang GUO
;
You-Song YANG
;
Hong-Yuan DAI
;
Wen-Bin WU
;
- Publication Type:Journal Article
- Keywords:
Free radical scavengers;
Antipyrine;
Cerebral hemorrhage;
Superoxide dismutase;
Malondial dehyde
- From:
Chinese Journal of Neurology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore therapeutic effects and mechanisms of radical scavenger edaravone on experimental cerebral hemorrhage.Methods Two hundred-forty male SD rats were divided randomly into four groups:control group,cerebral hemorrhage group,edaravone treatment group before operation (A) and edaravone treatment group after operation (B).Experimental cerebral hemorrhage model was made according to the method reported by Rosenberg.Water quantity contained in brain and nervous missing sign were observed,meanwhile the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in brain tissue were measured.Results Compared with cerebral hemorrhage group,nervous missing sign and water quantity contained in brain obviously changed in edaravone treatment group (P
