Effect of folate and vitamin B_(12) on tau phosphorylation in hippocampus of elderly rats
- VernacularTitle:叶酸和维生素B_(12)对老年大鼠海马中tau蛋白磷酸化的影响
- Author:
Jie-Wen ZHANG
;
Fen LU
;
Xu LI
;
Ai-Qin SUO
;
Wei LI
;
Liang-Fu ZHU
;
Li XIANG
;
Yue HUANG
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
tau proteins;
Phosphorylation;
Folic acid;
Vitamin B12
- From:
Chinese Journal of Neurology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of folates,vitamin B_(12) with tan phosphorylation and the possible mechanism in Alzhcimer's disease (AD).Method Tau protein phosphorylation was examined in hippocampns of rats of two months old and forty months old treated or untreated by folates and vitamin B_(12) using Western blot and immunohistochemistry with phosphorylation dependent and independent tau antibodies.Results We found that tau phosphorylation in aged rat brain showed a significant higher level than that in the two-month olds.Folates combined with vitamin.B_(12) could decrease tau phosphorylation by 27% at the site of Ser396/404 of hippoeampus in aged rats.Conclusion It suggests folates and vitamin B_(12) may play an important role in preventing the neurodegenerative change via effeeting tau phosphorylation in AD brain.