Thyroid autoantibodies In a five-year follow-up survey of populations with different Iodine intakes
- VernacularTitle:不同碘摄入量地区甲状腺自身抗体的流行病学五年随访研究
- Author:
Yu-Shu LI
;
Dong ZHAO
;
Zhong-Yan SHAN
;
Xiao-Chun TENG
;
Di TENG
;
Hai-Xia GUAN
;
Xiao-Hui YU
;
Chenling FAN
;
Wei CONG
;
Fan YANG
;
Hong DAI
;
Xiao-lan GU
;
Yang YU
;
Jin-yuan MAO
;
Jia LI
;
Yan-yan CHEN
;
Rong YANG
;
Ya-qiu JIANG
;
Chen-yang LI
;
Wei-ping TENG
;
- Publication Type:Journal Article
- Keywords:
Autoantibodies;
Antibodies;
thyroid peroxidase;
Antibodies;
thyroglobulin;
Epidemiologic studies;
Follow-up studies;
Iodine
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To perform a follow-up survey about thyroid disorders in three rural communities with different iodine intakes in China,observe the incidences and natural outcomes of positive thyroid autoantibodies in euthyroid population,and also explore the influence of iodine intakes on these outcomes and autoantibodies.Methods In 1999,a cross-sectional study on thyroid disorders was performed in three rural communities of Pansan ( mild iodine deficient area),Zhangwu ( more than adequate iodine intake area) and Huanghua (excessive iodine intake area) in China.The 5-year follow-up study was performed in 2004.Both in 1999 and 2004,serum levels of TSH,thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) were measured with the same method.Iodine in urine and B ultrasound on thyroid were also examined.Results Among the euthyroid subjects with normal TSH level in 1999,an increased prevalence of positive TPOAb in Zhangwu and an increased prevalence of positive TgAb in Hnanghua were observed in 2004 (both P＜0.05 ).Most of euthyroid subjects with positive TPOAb or positive TgAb in 1999 remained positive thyroid antibodies in 2004. The percentage was even higher in those with high levels of antibodies.Thyroid dysfunction was more frequent in subjects with positive TPOAb and/or TgAh than in those without thyroid antibodies (14.44% vs 3.11%,P＜0.01).For those with positive antibodies in 1999,the incidence of hypothyroidism in 2004 was 1.32%,8.46% and 15.38% in Pansan,Zhangwu and Huanghua,respectively (P＜0.05).The 5-year cumulative incidences of positive TPOAb (≥50 U/ml) and TgAb (≥40 U/ml) were 2.81% and 3.82%,respectively.The incidence of positive TPOAb was the highest in Zhangwu ( 3.84% ).The incidence of positive TgAb was the highest in Huanghua (5.07%),significantly higher than those in other two areas (P＜0.05).Conclusion The incidence of thyroid dysfunction is higher in subjects with positive antibodies than that in those with negative antibodies.The high iodine intake is a risk factor of hypothyroidism in subjects with positive thyroid antibodies.Sustained excessive iodine intake increases the incidence of positive thyroid antibodies.
