Iodine excess induces TRAIL expression of thyrocytes in rats
- VernacularTitle:高碘增加大鼠甲状腺细胞TRAIL表达
- Author:
Li-Li TIE
;
Ya-Ping ZHANG
;
Jian-Hu LI
;
Jian-Ying ZHANG
;
Min-Ge LI
;
Li-Hua LU
;
Qiu-He JI
- Publication Type:Journal Article
- Keywords:
Iodine;
Tumor necrosis factor-related apoptosis-inducing ligand;
Thyroiditis;
autoimmune
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Experimental autoimmune thyroiditis (EAT) animal model was established in female SD rats fed with high iodine diet.The concentrations of FT_3 and FT_4 were increasing in order of normal control group, iodine excess control group,EAT control group and EAT iodine excess group (Pl＜0.05 or P＜0.01).Semi- quantitative RT-PCR and Western-blotting results showed that the expression of TNF-related apoptosis-inducing ligand (TRAIL) existed in thyrocytes of each group,while the expression was increasing in order of normal control group,iodine excess control group,EAT control group and EAT iodine excess group (P＜0.01).The results suggested that high iodine diet might induce thyrocytes' apoptosis by increasing the expression of TRAIL and hence influencing functional and pathologic changes of thyroid grand.
