Expressions of hepatocyte growth factor and its receptor protein in human thyroid neoplasms
- VernacularTitle:甲状腺肿瘤中肝细胞生长因子及其受体蛋白的表达研究
- Author:
Li-Zhi SHANG
;
De-Xiang LI
;
Jun-Lian QIN
;
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Hepathocyte growth factor;
Proto-oncogene protein c-met;
Immunohistochemistry
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The expressions of hepatocyte growth factor (HGF) and its receptor (c-Met) protein were examined by immunohistochemistry in benign and malignant thyroid neoplasms.The results showed that the positive rates of HGF and c-Met protein expressions in thyroid carcinomas were significantly higher than those of thyroid adenomas,and especially the expressions of HGF and c-Met proteins in follicular thyroid carcinomas were significantly higher than those in follicular thyroid adenomas.There existed significantly positive correlation between the expression degrees of HGF and c-Met in follicular thyroid carcinoma.Thus,the expressions of HGF and c-Met may be valuable in predicting prognosis of thyroid carcinomas and differentiating benign from malignant thyroid neoplasms.
