Association of calcium channel?1 subunit gene - 1551T/C polymorphisms with thyrotoxic periodic paralysis
- VernacularTitle:钙通道?1亚基基因11外显子1551位点T/C多态性与甲亢性周期性麻痹的相关性研究
- Author:
Jian-Xia HU
;
Sheng-Li YAN
;
- Publication Type:Journal Article
- Keywords:
Hypokalemic periodic paralysis;
Hyperthyroidism;
Calcium channel?l subunit;
Polymorphism;
genetic
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The association of polymorphisms of calcium channel?1 subunit ( Cav1.1 ) gene ( - 1551T/C at exon 11 ) with thyrotoxic periodic paralysis (TPP) was investigated by PCR-RFLP.The distributions and frequencies of - 1551TC + CC genotype and C allele in TPP group were significantly higher than those in hyperthyroidism (HT) and normal control (CON) groups.There was no statistic difference between HT and CON groups.Cavl.1 gene - 1551TC + CC genotype and allele may contribute to the development of TPP in male HAN population from North China.
