Influence of islet 11?-HSD1 expression on islet?-cell function in streptozotocin and high-fat induced diabetic rats
- VernacularTitle:2型糖尿病大鼠胰岛11?-类固醇脱氢酶1型的表达对?细胞功能的影响
- Author:
Ai-Ping ZHANG
;
Mu-Xun ZHANG
;
Jian-Hua ZHANG
;
Yi-Kai YU
;
- Publication Type:Journal Article
- Keywords:
11?-hydroxysteroid dehydrogenase type 1;
Diabetes meUitus;
experimental;
Islet?-cells;
Glucocorticoids
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Intraperitoneal glucose tolerance test was performed in the streptozotocin- and high fat-induced diabetic rats and normal rats.The results of RT-PCR and Western blot showed that the expression of 11?- hydroxysleroid dehydrogenase type 1 (11?-HSD1) was higher in the diabetic rats than that in control and was correlated with fasting plasma glucose,insulin and AUC-I/G with respective correlation coefficient (r) of 0.870, - 0.799,- 0.850,suggesting that increased expression of 11?-HSD1 appears to damage?-cell function through magnifying the local effect of glucocorticoids.
